Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism
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- Giamarellos-Bourboulis Evangelos J.
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Spyridaki Aikaterini
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Savva Athina
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Georgitsi Marianna
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Tsaganos Thomas
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Mouktaroudi Maria
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Raftogiannis Maria
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Antonopoulou Anastasia
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Papaziogas Vassilios
- Second Department of Surgery, University of Thessaloniki, Medical School, Greece
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- Baziaka Fotini
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Sereti Kalliopi
- Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece
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- Christopoulos Petros
- Second Department of Surgery, University of Thessaloniki, Medical School, Greece
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- Marioli Androniki
- Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece
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- Kanni Theodora
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Maravitsa Panagiota
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Pantelidou Ilianna
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Leventogiannis Konstantinos
- Fourth Department of Internal Medicine, University of Athens, Medical School, Greece
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- Tsiaoussis Panagiotis
- Second Department of Surgery, University of Thessaloniki, Medical School, Greece
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- Lymberopoulou Korina
- Second Department of Internal Medicine, “Sismanogleion” Athens Hospital, Greece
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- Koutelidakis Ioannis M.
- Second Department of Surgery, University of Thessaloniki, Medical School, Greece
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Description
One prospective, open-label, non-randomized study was conducted in 100 patients to define the antipyretic and analgesic effect of a new intravenous formulation of 1 g of paracetamol; 71 received paracetamol for the management of fever and 29 received paracetamol for pain relief after abdominal surgery or for neoplastic pain. Serial follow-up measurements of core temperature and of pain intensity were done for 6 h. Additional rescue medications were recorded for 5 days. Blood was sampled for the measurement of free paracetamol (APAP) and of glucuronide-APAP and N-sulfate-APAP by an HPLC assay. Defervescence, defined as core temperature below or equal to 37.1°C, was achieved in 52 patients (73.2%) within a median time of 3 h. Patients failing to become afebrile with the first dose of paracetamol became afebrile when administered other agents as rescue medications. Analgesia was achieved in 25 patients (86.4%) within a median time of 2 h. Serum levels of glucuronide-APAP were greater among non-responders to paracetamol. The presented results suggest that the intravenous formulation of paracetamol is clinically effective depending on drug metabolism.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 124 (2), 144-152, 2014
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205179158656
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- NII Article ID
- 130003391475
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- NII Book ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXkt1egtrY%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 025296114
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- PubMed
- 24553403
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed