Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ₂₅₋₃₅/IFN-γ-Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

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  • Qi Yue
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China Department of Pharmacology, The Second Hospital Affiliated to Liaoning Chinese Medical University, China
  • Zou Li-Bo
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China
  • Wang Li-Hua
    Shenyang Institute of Applied Ecology, Chinese Academy of Sciences, China
  • Jin Ge
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China
  • Pan Jin-Jin
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China
  • Chi Tian-Yan
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China
  • Ji Xue-Fei
    Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, China

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タイトル別名
  • Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in A<i>β</i><sub>25–35</sub>/IFN-<i>γ</i>–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-<i>κ</i>B, and Mitogen-Activated Protein Kinase Signaling Pathways
  • Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

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説明

An accumulating body of evidence suggests that Alzheimer’s disease (AD) is associated with microglia-mediated neuroinflammation and pro-inflammatory cytokine expression. Therefore, the suppression of neuroinflammation and pro-inflammatory cytokine might theoretically slow down the progression of AD. Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has potent antiinflammatory and neuroprotective effects. However, the molecular mechanism underlying its anti-inflammatory action remains unclear. In the present study, we attempted to determine the effects of xanthoceraside on the production of pro-inflammatory mediators in amyloid β25–35 (Aβ25–35) / interferon-γ (IFN-γ)-stimulated microglia. Our results indicated that xanthoceraside (0.01 and 0.1 μM) significantly inhibited the release of nitric oxide (NO) and pro-inflammatory cytokines interleukin-1β and tumor necrosis factor-α in a concentration-dependent manner. Reverse transcriptase–polymerase chain reaction and western blotting analyses showed that xanthoceraside decreased the Aβ25–35/IFN-γ–induced production of cyclooxygenase-2 and inducible NO synthase. These effects were accompanied by inhibited activities of nuclear factor-κB and mitogen-activated protein kinase through Toll-like receptor 2 in a myeloid differentiation protein 88–dependent manner. Our results provide support for the therapeutic potential of xanthoceraside in AD.

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