Bone regeneration using osteogenic stem cell and sonic hedgehog gene

DOI 18 References
  • Ueda Minoru
    Nagoya University School of Medicine, Department of Oral and Maxillofacial Surgery

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  • 幹細胞と遺伝子を用いた骨の再生医療

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Abstract

In this article the general strategy for bone regeneration using osteogenic stem cell and gene modified cells. In the past autogenous bone grafting was the most reliable and well documented technique for bone regeneration. However the patient usually is demanded the heavy burden for harvesting the grafted bone in the donor sites. In this circumstances the tissue engineering concept has been developed and introduced for clinical use.<BR>In this article the general strategy for bone regeneration using tissue engineering concept. We have tried two essential elements such as mesenchymal stem cell and sonic hedgehog gene to generate the bone tissue.<BR>Marrow expanded mesenchymal stem cell with ceramics scaffold have been studied and confirmed its usability for bone engineering especially for cavitary bone defects in the jaw bone. Also the sonic hedgehog gene modified fibroblasts could be useful for the systemic bone disease such as osteoporosis.

Journal

  • Ensho Saisei

    Ensho Saisei 23 (5), 262-268, 2003

    The Japanese Society of Inflammation and Regeneration

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