Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors
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- Hibino Tomoko
- Tsumura Research Laboratories, Tsumura & Co., Japan
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- Yuzurihara Mitsutoshi
- Tsumura Research Laboratories, Tsumura & Co., Japan
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- Kase Yoshio
- Tsumura Research Laboratories, Tsumura & Co., Japan
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- Takeda Atsushi
- Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
Bibliographic Information
- Other Title
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- Goshuyuto, a traditional Japanese medicine, and aqueous extracts of Evodiae Fructus constrict isolated rat aorta via adrenergic and/or serotonergic receptors
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Abstract
We investigated the effects of Evodiae Fructus and synephrine, one of the components of Evodiae Fructus, on blood vessels. We found that Evodiae Fructus (1 × 10−6 – 3 × 10−4 g/mL) had constrictive effects on rat aorta. The vasoconstrictive effects of Evodiae Fructus were significantly inhibited by pretreatment with prazosin (adrenergic α1-receptor antagonist), BRL15572 [5-hydroxytryptamine (5-HT)1D antagonist], and ketanserin (5-HT2A antagonist), but its vasoconstrictive effects were not inhibited by pretreatment with SB216641 (5-HT1B antagonist) or propranolol (adrenergic β-receptor antagonist). These results suggest that Evodiae Fructus constricts rat aorta via adrenergic and serotonergic receptors. We also investigated the constrictive effects of synephrine on blood vessels. The vasoconstrictive effects of synephrine (1 × 10−7 – 3 × 10−5 mol/L) were significantly inhibited by pretreatment with prazosin, BRL15572, and ketanserin. However, its constrictive effects were not inhibited by pretreatment with SB216641 and propranolol. The pA2 values of prazosin or ketanserin were nearly equal between Evodiae Fructus and synephrine. Because the constrictive effects of both Evodiae Fructus and synephrine were exerted via adrenergic α1-receptors and serotonergic (5-HT1D and 5-HT2A) receptors, synephrine may be one of the important components in the constrictive effects of Evodiae Fructus.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 111 (1), 73-81, 2009
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205179543168
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- NII Article ID
- 10025738703
- 110007042156
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13475215
- 13478613
- 09186158
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed