A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis
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- Shinohara Mitsuko
- Depatment of Pharmacology, Osaka Dental University, Japan
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- Nagasaka Kuniko
- Fukae Nagasaka Clinic, Japan
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- Nakagawa Hideyuki
- Depatment of Pharmacology, Osaka Dental University, Japan Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
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- Edo Kozue
- Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
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- Sakai Hitomi
- Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokushima Graduate School, Japan
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- Kato Koji
- Depatment of Pharmacology, Osaka Dental University, Japan
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- Iwaki Futoshi
- Depatment of Pharmacology, Osaka Dental University, Japan
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- Ohura Kiyoshi
- Depatment of Pharmacology, Osaka Dental University, Japan
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- Sakuraba Haruhiko
- Department of Applied Biological Sciences, Kagawa University, Japan
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Abstract
A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 113 (4), 414-417, 2010
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205179579648
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- NII Article ID
- 10027746301
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 10790729
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed