Emerging New Roles of GM130, a cis-Golgi Matrix Protein, in Higher Order Cell Functions

DOI Web Site 被引用文献5件 参考文献178件
  • Nakamura Nobuhiro
    Cell Biology, Division of Life Science, Graduate School of Natural Science and Technologies, Kanazawa University, Japan School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan

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GM130 is a peripheral membrane protein strongly attached to the Golgi membrane and is isolated from the detergent and salt resistant Golgi matrix. GM130 is rich in coiled-coil structures and predicted to take a rod-like shape. Together with p115, giantin, and GRASP65, GM130 facilitates vesicle fusion to the Golgi membrane as a vesicle “tethering factor”. GM130 is also involved in the maintenance of the Golgi structure and plays a major role in the disassembly and reassembly of the Golgi apparatus during mitosis. Emerging evidence suggests that GM130 is involved in the control of glycosylation, cell cycle progression, and higher order cell functions such as cell polarization and directed cell migration. This creates the potential for novel Golgi-targeted drugs and treatments for various diseases including glycosylation defects, immune diseases, and cancer.

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