Life Style-Related Diseases of the Digestive System: Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment
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- Takahashi Hirokazu
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Yoneda Kyoko
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Tomimoto Ayako
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Endo Hiroki
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Fujisawa Toshio
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Iida Hiroshi
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Mawatari Hironori
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Nozaki Yuichi
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Ikeda Tamon
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Akiyama Tomoyuki
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Yoneda Masato
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Inamori Masahiko
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Abe Yasunobu
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Saito Satoru
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Nakajima Atsushi
- Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan
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- Nakagama Hitoshi
- Biochemistry Division, National Cancer Center Research Institute, Japan
Bibliographic Information
- Other Title
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- Colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment
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Abstract
Life style-related diseases are associated with an increased risk of colorectal cancer (CRC). Recently, an association has been demonstrated between obesity and CRC. CRC has been associated with markers of insulin or glucose control, and insulin resistance might be the unifying mechanism by which several risk factors affect colorectal carcinogenesis. We evaluated the association between the number of aberrant crypt foci (ACF) and obesity, insulin resistance, hyperlipidemia, and other factors of life style-related disease. As a result, age, body mass index (BMI), waist circumference, and visceral fat obesity were significantly associated with the number of ACF. These results suggest that visceral fat obesity is an important target for CRC prevention. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor superfamily and is highly expressed in CRC. PPARγ ligand administration for 1 to 8 months significantly reduced the number of ACF in human subjects. PPARγ ligand is a promising candidate as a chemopreventive agent. Further investigation is needed to elucidate these mechanisms.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 105 (2), 129-132, 2007
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205179854208
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- NII Article ID
- 10024316019
- 130000075717
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 8965930
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed