Suppression of Histamine Signaling by Probiotic Lac-B: a Possible Mechanism of Its Anti-allergic Effect

DOI Web Site PubMed 8 Citations 63 References Open Access
  • Dev Shrabanti
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
  • Mizuguchi Hiroyuki
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
  • Das Asish K.
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
  • Matsushita Chiyo
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
  • Maeyama Kazutaka
    Division of Pharmacology, Department of Integrated Basic Medical Science, Ehime University School of Medicine, Japan
  • Umehara Hayato
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
  • Ohtoshi Takayuki
    Ohtoshi Clinic, Japan
  • Kojima Jun
    Clinical Research Group, Clinical Development Department, Kowa Pharmaceutical Co., Ltd., Japan
  • Nishida Kiyotaka
    Clinical Research Group, Clinical Development Department, Kowa Pharmaceutical Co., Ltd., Japan
  • Takahashi Kunihiko
    Clinical Research Group, Clinical Development Department, Kowa Pharmaceutical Co., Ltd., Japan
  • Fukui Hiroyuki
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan

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It has been shown that probiotic bacteria are effective for the treatment of allergic diseases. As histamine plays a central role in allergic diseases, it is possible that probiotic bacteria affect the allergy-related histamine signaling. Here, we investigated the effect of Lac-B, a mixture of freeze-dried Bifidobacterium infantis and Bifidobacterium longum, on the allergy-related histamine signaling. In the nasal allergy model rats made by sensitization and provocation with toluene 2,4-diisocyanate (TDI) for 3 weeks, TDI provocation caused acute allergy–like behaviors along with significant up-regulation of histamine H1 receptor (H1R) and histidine decarboxylase (HDC) mRNA expression, increased HDC activity, histamine content, and [3H]mepyramine binding activity in nasal mucosa. Prolonged treatment with Lac-B (40 mg/rat, p.o.) significantly suppressed both the allergy-like behaviors and all of the above mentioned factors involved in histamine signaling. Our findings indicate that oral administration of Lac-B showed significant anti-allergic effect through suppression of both H1R and HDC gene expression followed by decrease in H1R, HDC protein level, and histamine content. Suppression of histamine signaling may be a novel target of probiotics in preventing allergic diseases.<br>

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