Prevention of Topical Surfactant^|^ndash;Induced Itch-Related Responses by Chlorogenic Acid Through the Inhibition of Increased Histamine Production in the Epidermis
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- Inami Yoshihiro
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan Fundamental Research Laboratory, Hoyu Co., Ltd., Japan
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- Andoh Tsugunobu
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
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- Kuraishi Yasushi
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
書誌事項
- タイトル別名
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- Prevention of Topical Surfactant–Induced Itch-Related Responses by Chlorogenic Acid Through the Inhibition of Increased Histamine Production in the Epidermis
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抄録
Effects of chlorogenic acid on surfactant-induced itching were studied in mice. Topical application of sodium laurate increased hind-paw scratching, an itch-related response, 2 h after application, which was inhibited by topical post-treatment with chlorogenic acid. Sodium laurate increased the histamine content and 53-kDa l-histidine decarboxylase in the epidermis, which were also inhibited by post-treatment with chlorogenic acid. These results suggest that topical chlorogenic acid is effective in the prevention of itching induced by anionic surfactants. The inhibitory activity of chlorogenic acid may be due to the inhibition of an increase in histamine in the epidermis.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 121 (3), 242-245, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180632832
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- NII論文ID
- 10031165469
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BC3svitFCktQ%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024351398
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- PubMed
- 23449492
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可