Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats
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- Kuwahara Rika
- Graduate School of Science and Technology, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Japan
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- Kawaguchi Shinichiro
- Graduate School of Science and Technology, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Japan
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- Kohara Yumi
- Graduate School of Fisheries Science and Environmental Studies, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Japan
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- Cui Haiming
- Graduate School of Fisheries Science and Environmental Studies, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Japan
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- Yamashita Kimihiro
- Division of Environmental Chemistry and Ecotoxicology, Institute of Environmental Studies, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Japan
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Bisphenol A (BPA) is an estrogenic endocrine disruptor used for producing polycarbonate plastics and epoxy resins. This study investigated the effects of perinatal BPA exposure on learning and memory, general activity, and emotionality in male Sprague Dawley rats using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) used to assess spatial learning and memory. Mother rats were orally administered BPA (50 or 500 μg∙kg−1/day) or vehicle (1 ml∙kg−1/day) from gestational day 10 to postnatal day 14. In the MAZE test, compared to the offspring of vehicle-treated rat mothers, male offspring of mothers exposed to 50 μg∙kg−1/day of BPA, but not those of mothers exposed to 500 μg∙kg−1/day of BPA, needed significantly more time to reach the reward. Although male offspring of mothers exposed to 50 μg∙kg−1/day of BPA showed an increase in a behavioral measure of wariness after repeated testing in the open-field test, no significant effects were observed in locomotor activities. No significant differences were observed in any other behavioral test including the elevated plus-maze test. The present study suggests that perinatal exposure to low-dose BPA specifically and non-monotonically impairs spatial learning and memory in male offspring rats.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 123 (2), 132-139, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180660736
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- NII論文ID
- 130003382592
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3sXhslertrrP
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- ISSN
- 13478648
- 13478613
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- HANDLE
- 10069/34155
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- NDL書誌ID
- 024954756
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- PubMed
- 24077108
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可