Effects of Millettia macrophylla (Fabaceae) Extracts on Estrogen Target Organs of Female Wistar Rat
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- Zingue Stéphane
- Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon Laboratory of Physiology, Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, Cameroon Division of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Greece
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- Njamen Dieudonné
- Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon
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- Tchoumtchoua Job
- Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon Division of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Greece
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- Halabalaki Maria
- Division of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Greece
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- Simpson Evan
- Prince Henry’s Institute of Medical Research, Monash Medical Centre, Australia
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- Clyne Colin
- Prince Henry’s Institute of Medical Research, Monash Medical Centre, Australia
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- Magne Nde Chantal Beatrice
- Prince Henry’s Institute of Medical Research, Monash Medical Centre, Australia
書誌事項
- タイトル別名
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- Effects of <i>Millettia macrophylla</i> (Fabaceae) Extracts on Estrogen Target Organs of Female Wistar Rat
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The present study aims to determine the estrogenicity of Millettia macrophylla, a Cameroonian medicinal plant, in ovariectomized rats and to investigate the underlying mechanisms, in order to justify scientifically its traditional use. To accomplish this objective, we used dichloromethane (DCM) and methanol (MeOH) extracts of the stem bark of M. macrophylla. In the cell culture based assay, the MeOH extract significantly transactivated estrogen receptor α (ERα) and estrogen receptor β (ERβ); in addition, the estrogen-like effects of both, DCM and MeOH extracts, could be inhibited in vitro by the pure ER antagonist ICI 182,780, indicating that these effects were primarily mediated through ERs. In animal experiments, both DCM and MeOH extracts significantly increased the uterine and vaginal epithelial heights in the 3-day treatment assay, while only the MeOH extract exhibited such effects in the sub-chronic treatment regimen. Furthermore, the MeOH extract significantly decreased fasting serum triglycerides, total cholesterol levels and artherogenic risk in the sub-chronic treatment. These results indicate that M. macrophylla extracts have estrogen-like effects supporting their traditional use in Cameroon to alleviate some menopausal problems (See graphical abstract in Supplementary Fig. 1, available in the online version only).
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 123 (2), 120-131, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180662144
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- NII論文ID
- 130003382593
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3sXhslertrrO
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024954736
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- PubMed
- 24077107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可