Effects of Propofol on Electrocardiogram Measures in Mice
-
- Shintaku Tomohiro
- Department of Pharmacology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Ohba Takayoshi
- Department of Cell Physiology, Akita University, Graduate School of Medicine, Japan
-
- Niwa Hidetoshi
- Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Kushikata Tetsuya
- Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Hirota Kazuyoshi
- Department of Anesthesiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Ono Kyoichi
- Department of Cell Physiology, Akita University, Graduate School of Medicine, Japan
-
- Matsuzaki Yasushi
- Department of Dermatology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Imaizumi Tadaatsu
- Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Kuwasako Kenji
- Division for Identification and Analysis of Bioactive Peptides, University of Miyazaki, Japan
-
- Sawamura Daisuke
- Department of Dermatology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
-
- Murakami Manabu
- Department of Pharmacology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Japan
この論文をさがす
抄録
We investigated the anesthetic effects of propofol on the electrocardiogram (ECG) in mice. We also compared the effects of isoflurane (2%) inhalation anesthesia, intraperitoneal propofol (50 or 100 mg/kg), and pentobarbital (50 mg/kg) on ECG in mice. Isoflurane inhalation and pentobarbital anesthesia were both associated with an acceptable heart rate (HR) range (ca. 450 – 500 bpm). In contrast, high-dose propofol anesthesia significantly decreased the HR. Importantly, propofol anesthesia led to significantly reduced responses to propranolol, a β-blocker, suggesting that it affects sympathetic tonus and is not suitable for the evaluation of cardiovascular or sympathetic function. Propofol also reduced the response to atropine, indicative of suppression of mouse parasympathetic nerve activity. Our data suggest that propofol anesthesia should not be the first choice for cardiovascular analysis in mice.
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 126 (4), 351-358, 2014
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205180710144
-
- NII論文ID
- 40020313633
- 130004704287
-
- NII書誌ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 026003927
-
- PubMed
- 25409900
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可