Salidroside Attenuates Apoptosis in Ischemic Cardiomyocytes: a Mechanism Through a Mitochondria-Dependent Pathway
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- Zhong Han
- Department of Pharmacology, School of Pharmacy, Fudan University, China
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- Xin Hong
- Department of Pharmacology, School of Pharmacy, Fudan University, China
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- Wu Li-Xin
- Department of Pharmacology, School of Pharmacy, Fudan University, China
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- Zhu Yi-Zhun
- Department of Pharmacology, School of Pharmacy, Fudan University, China
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説明
In the present study, we investigated cardioprotective effects of salidroside, isolated from Rhodiola rosea L, on oxygen–glucose deprivation (OGD)-induced cardiomyocyte death and ischemic injury evoked by acute myocardial infarction (AMI) in rats. Pretreatment with salidroside notably ameliorated cell viability losses in a dose-dependant manner and in parallel it alleviated morphologic injury detected by electron microscopy. Mechanistically, diminished OGD-induced cardiomyocyte apoptosis was shown in salidroside-pretreated cardiomyocytes, in accordance with minimal reactive oxygen species (ROS) burst. Moreover, salidroside markedly upregulated the Bcl-2/Bax ratio and preserved mitochondrial transmembrane potential (ΔΨm). Salidroside administration also inhibited myocardial apoptosis in AMI rats by increasing phosphorylation of Akt and decreasing activation of caspase-3. These findings suggest that salidroside reduced ischemia-mediated myocardial damage. Salidroside therefore has potential to be a promising drug for preventing and treating myocardial ischemic diseases.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 114 (4), 399-408, 2010
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205180763648
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- NII論文ID
- 10029890970
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3MXisFOmtg%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10926432
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- PubMed
- 21160132
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
