Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil^|^ndash;Induced Oral Mucositis

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  • Watanabe Shinichi
    Division of Pharmacy, Ehime University Hospital, Japan
  • Suemaru Katsuya
    School of Pharmacy, Shujitsu University, Japan
  • Takechi Kenshi
    Division of Pharmacy, Ehime University Hospital, Japan
  • Kaji Hiroaki
    Division of Biochemistry, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Japan
  • Imai Kimie
    Division of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
  • Araki Hiroaki
    Division of Pharmacy, Ehime University Hospital, Japan

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  • Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil–Induced Oral Mucositis

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Oral mucositis induced by chemotherapy or radiotherapy has an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan–sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU–induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.

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