Type A1 but Not Type A2 Botulinum Toxin Decreases the Grip Strength of the Contralateral Foreleg Through Axonal Transport From the Toxin-Treated Foreleg of Rats
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- Torii Yasushi
- The Chemo-Sero-Therapeutic Research Institute (KAKETSUKEN), Japan
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- Akaike Norio
- Research Division for Life Science, Kumamoto Health Science University, Japan
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- Harakawa Tetsuhiro
- The Chemo-Sero-Therapeutic Research Institute (KAKETSUKEN), Japan
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- Kato Keiko
- Department of Animal Medical Sciences, Kyoto Sangyo University, Japan
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- Sugimoto Nakaba
- Department of Molecular Therapeutics, Medical School of Osaka University, Japan
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- Goto Yoshitaka
- The Chemo-Sero-Therapeutic Research Institute (KAKETSUKEN), Japan
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- Nakahira Shinji
- The Chemo-Sero-Therapeutic Research Institute (KAKETSUKEN), Japan
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- Kohda Tomoko
- Department of Veterinary Sciences, School of Life and Environmental Sciences, Osaka Prefecture University, Japan
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- Kozaki Shunji
- Department of Veterinary Sciences, School of Life and Environmental Sciences, Osaka Prefecture University, Japan
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- Kaji Ryuji
- School of Medicine, University of Tokushima Faculty of Medicine, Japan
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- Ginnaga Akihiro
- The Chemo-Sero-Therapeutic Research Institute (KAKETSUKEN), Japan
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抄録
The adverse effects of botulinum LL toxin and neurotoxin produced by subtype A1 (A1LL and A1NTX) are becoming issues, as the toxins could diffuse from the toxin-treated (ipsilateral) to contralateral muscles. We have attempted to produce neurotoxin from subtype A2 (A2NTX) with an amino acid sequence different from that of neurotoxin subtype A1. We measured the grip strength on the contralateral foreleg as an indicator of toxin spread from the ipsilateral to contralateral muscles. Doses of 0.30 log U or above of A1LL and A1NTX reduced the contralateral grip strength, whereas a dose of 0.78 log U of A2NTX was required to do so. We investigated the route of toxin spread using denervated, colchicine-treated, and antitoxin-treated rats. A1LL was transported via axons at doses higher than 0.30 log U and via both axons and body fluid at about 0.80 log U or a higher dose. Interestingly, A2NTX was transported via body fluid at about 0.80 log U or a higher dose, but not via axons to the contralateral side. It was concluded that A1LL and A1NTX decreased the grip strength of the toxin-untreated foreleg via both axonal transport and body fluids, while A2NTX was only transported via the body fluid.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 117 (4), 275-285, 2011
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205181333760
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- NII論文ID
- 10030453790
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 023386107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 使用不可