The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts
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- Kobayashi Daisaku
- Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
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- Kusama Miho
- Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
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- Onda Masaaki
- Daiichi Fine Chemical Co., Ltd., Japan
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- Nakahata Norimichi
- Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
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Abstract
It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. However, few studies have investigated the mechanism of action of pantothenic acid on skin tissues. We tried to clarify the role of pantothenic acid on skin function by using keratinocytes and fibroblasts. The depletion of pantothenic acid from the culture medium suppressed keratinocyte proliferation and promoted differentiation. Moreover, pantothenic acid depletion decreased the synthesis of keratinocyte growth factor and procollagen 4a2 in fibroblasts. These results suggest that pantothenic acid is essential for maintaining keratinocyte proliferation and differentiation.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 115 (2), 230-234, 2011
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205181358464
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- NII Article ID
- 10029892223
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- NII Book ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3MXivVKrtbw%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 10979859
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- PubMed
- 21258175
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed