Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

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  • Nakajima Akira
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
  • Yamakuni Tohru
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
  • Haraguchi Mitsuya
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
  • Omae Naoki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
  • Song Si-Young
    Institute of Neuroscience, Tokushima Bunri University at Kagawa, Japan
  • Kato Chieko
    Institute of Neuroscience, Tokushima Bunri University at Kagawa, Japan
  • Nakagawasai Osamu
    Department of Pharmacology, Tohoku Pharmaceutical University, Japan
  • Tadano Takeshi
    Department of Pharmacology, Tohoku Pharmaceutical University, Japan
  • Yokosuka Akihito
    Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
  • Mimaki Yoshihiro
    Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
  • Sashida Yutaka
    Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
  • Ohizumi Yasushi
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan Yokohama College of Pharmacy, Japan Research Center of Supercritical Fluid Technology, Graduate School of Engineering, Tohoku University, Japan

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  • A citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice

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We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.<br>

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