Availability of Estrogen-containing Topical Solution for Female Pattern Hair Loss

DOI
  • ITO Taisuke
    Department of Dermatology, Hamamatsu University School of Medicine
  • TOKURA Yoshiki
    Department of Dermatology, Hamamatsu University School of Medicine
  • MAEJIMA Hideki
    Department of Dermatology, Kitasato University School of Medicine
  • AMOH Yasuyuki
    Department of Dermatology, Kitasato University School of Medicine
  • INUI Shigeki
    Shinsaibashi Inui Dermatology Clinic
  • ITAMI Satoshi
    Department of Regenerative Dermatology, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title
  • 女性における男性型脱毛症患者に対する女性ホルモン含有育毛剤の使用試験

Description

Effective treatment for female pattern hair loss (FPHL) has been eagerly desired for several decades. In this study, we assessed the safety and efficacy of ethinyl estradiol-containing topical solution for FPHL. Thirty patients with FPHL were enrolled in this study, and ethinyl estradiol-containing solution was topically applied on the scalp hair loss area twice a day for 24 weeks. Twenty patients finished this study, and were assessed by clinical and subjective symptoms, QOL, efficacy, and safety. After using the solution for 24 weeks, we observed marked improvement of the “degree of baldness” (clinical symptom) and “degree of hair loss” (subjective symptom). Significant reduction in the amount of hair loss has been observed in the subjective symptoms after 4 weeks and in Visual Analog Scale (VAS) after 8 weeks. “Degree of baldness” was significantly improved after 12 weeks. It was suggested that ethinyl estradiol-containing solution may exhibit efficacy within a short period. Although adverse skin reactions (itching and erythema) were observed in 2 out of 22 cases, they disappeared by the discontinuation of the solution application. The ethinyl estradiol-containing solution should be suggested for mild FPHL.Skin Research, 15: 502-512, 2016

Journal

  • Hifu no kagaku

    Hifu no kagaku 15 (6), 502-512, 2016

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

  • CRID
    1390001205189768192
  • NII Article ID
    130005243064
  • DOI
    10.11340/skinresearch.15.6_502
  • ISSN
    18839614
    13471813
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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