A Case of Sarcoidosis with Affected Siblings

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  • 同胞に家族歴のあるサルコイドーシスの1例

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A 65-year-old woman was referred to us from the Ophthalmology Department of our university with suspected sarcoidosis. Laboratory testing was positive for elevated serum levels of angiotensin converting enzyme and soluble IL-2 receptor. A chest CT scan showed mediastinal lymphadenopathy and multiple nodules in the right lower lobe of the lung. Histological evaluation of a small erythematous lesion on the left knee demonstrated non-caseous epithelioid cell granulomas with multinucleated giant cells, including foreign bodies. Her elder brother had pulmonary sarcoidosis that required inpatient treatment with corticosteroids, and her elder sister was diagnosed with sarcoidosis of the lip; both siblings were diagnosed in their 20s. Her younger sister and brother have not been diagnosed with sarcoidosis. Familial sarcoidosis has been reported to occur frequently in siblings. Interestingly, the age at the time of diagnosis is similar among affected family members. The current case is rare given the significant age difference at the time of diagnosis between the patient and her affected siblings.Skin Research, 16: 125-128, 2017

Journal

  • Hifu no kagaku

    Hifu no kagaku 16 (2), 125-128, 2017

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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