Clinicopathological Analysis of Feline Renal Anemia

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  • 猫の腎性貧血の臨床病理学的検討

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Anemia is a common complication in cats with chronic kidney disease (CKD), but factors of renal anemia are various. We measured packed cell volume (PCV), creatinine, erythropoietin (EPO), serum ion, total iron binding capacity (TIBC) in 65 anemic cats with CKD and 10 clinically normal cats to investigate iron metabolic abnormalities in CDK cats. Both serum iron and TIBC were significantly less in the CKD cats than in the control cats, although there was no difference of EPO between the two groups. According to general knowledge, low serum iron and TIBC are consistent with anemia of chronic disease (ACD). In addition, there was a statistically significant positive correlation between EPO and TIBC in the CKD group in this study. These results suggest that ACD plays a primary role in renal anemia of CKD cats, and that EPO secretion depends on the degrees of concurrent illnesses rather than the severity of anemia or stages of CKD.

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