Usefulness of TARC in Serum as Treatment Marker and Combination Treatment with Loratadine and Steroid Ointment for Atopic Dermatitis

DOI 1 Citations
  • Kimura Utako
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Matsuba Shoichi
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Chikenji Takako
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Haruna Kunitaka
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Kamano Maya
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Suga Yasushi
    Department of Dermatology, Juntendo University Urayasu Hospital
  • Takamori Kenji
    Department of Dermatology, Juntendo University Urayasu Hospital

Bibliographic Information

Other Title
  • アトピー性皮膚炎患者に対する治療マーカーとしての血清TARCおよびステロイド外用薬とロラタジン併用療法の有用性の検討

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Description

In this study, 28 patients with mild or moderate atopic dermatitis were randomized to 4-week treatment with betamethasone valerate ointment (A group) or with loratadine tablet add-on (B group) to investigate changes in VAS for itch, SCORAD index, sIL-2R, TARC, and CTACK in serum. The VAS value, sIL-2R, and TARC significantly decreased in only B group. The SCORAD index in B group significantly decreased more than that of A group. A good positive correlation in changes between the serum TARC value and SCORAD index has been shown. Thus, the serum TARC value was considered a useful clinical marker. Furthermore, synergy effects of the combination therapy of topical corticosteroid and loratadine for the treatment of atopic dermatitis has been confirmed.

Journal

  • Hifu no kagaku

    Hifu no kagaku 8 (2), 125-131, 2009

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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