Clinical Study of Effect of Tranexamic Acid Emulsion on Melasma and Freckles

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  • トラネキサム酸配合乳液の肝斑・雀卵斑に対する使用成績

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Description

We investigated whether topical application of tranexamic acid(TA) emulsion is effective for improving the pigmentation in melasma and freckles. The subjects, 25 with melasma and 8 with freckles, used the TA emulsion for five to eighteen weeks, and the outcome was evaluated based on a doctor’s visual assessment of skin pigmentation. At the last observation point, TA emulsion had improved the pigmentation in melasma and freckles in 20 subjects(80%) with melasma and 6 subjects(75%) with freckles. No side effect was recognized, so TA emulsion is considered to be safe. As regards the time course, marked improvement was observed within 8 weeks for melasma, but within 12 weeks for freckles ; therefore, improvement was considered to require at least two months of topical application. We conclude that TA emulsion is an effective cosmeceutical product having a whitening effect on melasma and freckles through inhibition of melanin synthesis, and preventing the appearance of new pigmented spots and freckles.

Journal

  • Hifu no kagaku

    Hifu no kagaku 6 (3), 309-315, 2007

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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