Analysis of growth hormone gene sequences and polymorphisms in the Mongolian horse
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- HAI Hong
- United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
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- FUKUI Emiko
- United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
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- HASEGAWA Telhisa
- Equine Research Institute, Japan Racing Association
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- MATSUMOTO Hiromichi
- United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
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- MUKOYAMA Harutaka
- Nippon Veterinary and Life Science University
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- YOSHIZAWA Midori
- United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology Laboratory of Animal Breeding and Reproduction, Faculty of Agriculture, Utsunomiya University
Bibliographic Information
- Other Title
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- モンゴルウマにおける成長ホルモン遺伝子の塩基配列および多型解析
- モンゴルウマ ニ オケル セイチョウ ホルモン イデンシ ノ エンキ ハイレツ オヨビ タケイ カイセキ
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Abstract
The growth hormone genes in Mongolian, thoroughbred, Kiso, and Anglo-Arabian horses were analyzed and compared. In addition, polymorphism analysis of nucleotide substitutions in the growth hormone gene was performed using three local breeds of Mongolian horses (Wuzhumuqin : WZ, Wusen : WS, Baerhu : BH) and thoroughbred horses bred in China. The results showed that all the growth hormone genes contain 5 exons and 4 introns, with greater than 99% base sequence similarity. Nucleotide sequencing revealed a mutation of T/C at position 335 in exon4 of the growth hormone gene in Mongolian and thoroughbred horses, giving rise to an amino acid substitution. In addition, a T/C mutation at position 534 and a G/A mutation at position 558 in exon5 were also found in Mongolian, thoroughbred, Kiso and Anglo-Arabian horses. However, these mutations did not alter the amino acid sequence. The results of the present study indicate that individual local breeds of Mongolian horses differ in several characteristics of the growth hormone gene, with the BH horses showing the highest heterozygosity.
Journal
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- Nihon Chikusan Gakkaiho
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Nihon Chikusan Gakkaiho 80 (1), 1-6, 2009
Japanese Society of Animal Science
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Details 詳細情報について
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- CRID
- 1390001205191759488
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- NII Article ID
- 10029739807
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- NII Book ID
- AN00195188
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- ISSN
- 18808255
- 00215309
- 1346907X
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- NDL BIB ID
- 10184431
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed