遺伝変異体Ornithine Transcarbamylaseを有するヒナにおけるTransamidinase活性の変動

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タイトル別名
  • Dietary and Hormonal Regulation of Arginine Glycine Transamidinase Activity in Ornithine Transcarbamylase Variant Chicken
  • イデン ヘンイタイ Ornithine Transcarbamylase オ

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抄録

Experiments were conducted to reveal the effects of the dietary protein levels and fasting, and the administration of thyroxine, 17β-estradiol, testosterone propionate and hydrocortisone acetate on the activity of chick liver and kidney transamidinase (EC 2.1. 4.1.) involved in the biosynthesis of creatine. Two or four weeks old chicks used in these experiments were F1 of a California Gray breed male and While Leghorn B females posessing the heterozygote of variant ornithine transcarbamylase (OTC) gene. These chicks could be divided into the high OTC activity group and the low OTC activity one in the ratio of 1:1. The liver transamidinase activity was markedly repressed by the subcutaneous administration of 1mg of hydrocortisone to the level of the control chicks by the ratio of 1/6. After the single injection of hydrocortisone, the enzyme level decreased to a minimum level, 1/4 of the control level, in 3 days and then gradually recovered the normal level. No effect of hydrocortisone administration was observed at dose level less than 100μg per chick. Hormones other than hydrocortisone had little effects on hepatic or renal transamidinase activity. The experimental diet containing 75% casein, high protein diet, or 5% casein, low protein diet, feeding considerably repressed the liver and the kidney transamidinase activity. Fasting had the most severe effect on the transamidinase activity and lowered the level to 1/20 of that of the control value. In 24 hours of starvation, liver transamidinase activity lowered to 1/2 of the control value and then gradually decreased to the minimum level at 5 days of starvation. Refeeding of the diet to the starved chicks restored the enzyme activity and recovered the enzyme level to the 80% of the control value in 3 days. Marked repression of the liver transamidinase activity was observed with the administration of hydrocortisone and the fasting in accordance with severe inhibition of the growth of chicks. From these results, it has been suggested that there was a relationship between the growth of chicks and the liver transamidinase activity. No difference of the enzyme activity between the OTC-high and the OTC-low chicks in any treatment was observed.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 48 (5), 256-262, 1977

    公益社団法人 日本畜産学会

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