ヒナ甲状腺におけるホルモン合成と分泌におよぼすGoitrin投与量の影響

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書誌事項

タイトル別名
  • Effects of Graded Doses of Goitrin, a Goitrogen in Rapeseed, on Synthesis and Release of Thyroid Hormone in Chicks
  • ヒナ コウジョウセン ニ オケル ホルモン ゴウセイ ト ブンピ ニ オヨボス

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抄録

Intrathyroidal metabolism in synthesis and release of thyroid hormone was investigated in chicks administered three different levels of goitrin (0.0125, 0.025 and 0.05% in the diet) for 14 days. Thyroid glands were enlarged to 2-5 times as large as that of the control in proportion to the goitrin content of the diet. Typical high radioiodine uptake goiter was demonstrated in the goitrin-administered chicks. Total thyroid 125I content increased about twice as much as that of the control in the goitrin-administered chicks though it was depressed in 0.0065% PTU-administered chicks. Decrease of plasma PB 125I (approximately a half of the control) was ascertained by the estimation of plasma thyroxine by radiostereoassay. In the intrathyroidal metabolism of iodine, synthesis of iodothyronines and iodination of MIT were suppressed by goitrin, but monoiodination of tyrosine was rather accelerated. The elevated ratio of thyroid iodothyronines/plasma PBI (1.5-1.7 times as much as that of the control) reveals that the depression of plasma level of thyroid hormone is more striking than the decrease in thyroid hormone in the gland in the goitrin-administered chicks. It is, therefore, suggested that goitrin has inhibitory effects not only on the biosynthesis of thyroid hormone in the gland but also on the release of thyroid hormone from the gland.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 48 (12), 757-765, 1977

    公益社団法人 日本畜産学会

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