Study on Serum Cholesterol-Lowering Effect of Lactobacillus GG Lyophilized cells.

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  • Ｌａｃｔｏｂａｃｉｌｌｕｓ　ＧＧ凍結乾燥菌体の血清コレステロール低下作用に関する検討
  • Lactobacillus GG トウケツ カンソウ キンタイ ノ ケッセイ コレステロール テイカ サヨウ ニ カンスル ケントウ

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This study was conducted to evaluate the serum cholesterol-lowering effect of Lactobacillus GG lyophilized cells (GG cells) in in vitro and in vivo. In in vitro study, L. GG showed deconjugation activity of sodium taurocholate and cholesterol-binding ability. In in vivo study, 1% or 5% GG cells were administered to rats with high cholesterol diet for 14 days. Results show that the serum total cholesterol levels in experimental rats were significantly lower than in control rats fed only cholesterol diet (P<0.05, P<0.01). The inhibitory effect of the GG cells on serum cholesterol-rising was dose-dependent, and it is suggested that the effect might be due to cholesterol binding and deconjugation of bile acid by the GG cells.

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