The Effect of Atropine on Pancreatic Responses to Intravenous CCK-8 and Intraduodenal Soybean Extract in Sheep

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  • KATO Seiyu
    Departrment of Veterinary Medicine, The College of Dairying
  • ANDO Torn
    Departrment of Veterinary Medicine, The College of Dairying
  • ADACHI Noritaka
    Departrment of Veterinary Medicine, The College of Dairying
  • MINED Hitoshi
    Departrment of Veterinary Medicine, The College of Dairying
  • USHIJIMA Jun-ichi
    Departrment of Veterinary Medicine, The College of Dairying

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Other Title
  • めん羊の静脈内CCK-8および十二指腸内大豆抽出液投与に対する膵外分泌反応に及ぼすアトロピンの影響
  • メンヨウ ノ ジョウミャクナイ CCK-8 オヨビ ジュウニシチョウナイ ダイ

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Abstract

The effects of intravenous infusion of atropine on pancreatic exocrine responses to exogenous CCK-8 and to endogenous CCK-PZ released by intraduodenal administration of soybean extract were examined in sheep. Atropine did not inhibit the response of exocrine pancreas to CCK-8 injected intravenously. Intraduodenal administration of soybean extract increased juice flow (2.87-fold), protein output (3.71-fold) and amylase output (3.56-fold), which were significantly inhibited by atropine infusion showing a small increase of juice flow but no increases of protein and amylase outputs. These results indicate that the cholinergic mechanism is not involved in the action of CCK-8 on pancreatic acinar cell, but the release of CCK-PZ from intestinal mucosal cell is considerably mediated by the cholinergic mechanism in sheep.

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