マウスの発情周期に及ぼすたん白質の給与レベルと給与日数の影響

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タイトル別名
  • Influence of Different Dietary Protein Levels and Feeding Periods on the Estrous Cycle in Female Mice
  • マウス ノ ハツジョウ シュウキ ニ オヨボス タンパクシツ ノ キュウヨ レ

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The present study was to examine the influence of feeding three different levels of dietary protein on the estrous cycle in mice. Adult virgin mice of ICR-JCL strain weighing 30.7g at 60-65 days of age and exhibiting regular estrous cycles during 14 days before experiments were used. Composition of diets and feeding conditions were almost similar to those as in our previous paper1). Protein levels in the diets were 15% crude protein (CP) (low), 25% CP (standard) and 35% CP (high). In experiment I, 90 mice in total were divided into 3 groups of 30 mice each. Three groups of mice were fed with different dietary protein levels for 21, 31 and 41 days and estrous cycle was investigated for 21 days starting from the 1st, the 11th and the 21st day of experimental feeding. In experiment II, 240 mice in total were divided into 3 groups of 80 mice each. Three groups of mice were fed with experimental diet as in the experiment I. Mating (formation of vaginal plug) was investigated starting from the 2nd, the 10th, the 20th and the 30th day of feeding with experimental diet. The results obtained are summarized as follows. 1) The duration of one estrous cycle in mice fed with either high or low protein ration, was significantly longer than that of the mice fed with standard ration, and the number of recurrent estrous cycle within three weeks decreased in the experimental mice as compared with that of the control mice. The prolonged estrous cycle in mice fed with low protein ration was due to the extention of both estrous and diestrous stages. 2) Duration from the introduction of male mice into the female mice to the detection of vaginal plug prolonged in the mice fed with either high or low protein ration as compared with that of the control mice, and this prolongation became remarkable as the feeding periods were extended. However, the vaginal plug was observed even in the experimental mice within five days after the introduction of male mice, and ovulation was also confirmed at autopsy. From the results mentioned above it was suggested that the formation of vaginal plug followed by the ovulation was induced by the stimulus from the excitation or mounting of the male. Therefore, depression in the conception rate and the prolongation of delivery interval in mice fed with high or low protein rations might be due to abnormal fertilization or the failure of implantation.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 51 (8), 561-567, 1980

    公益社団法人 日本畜産学会

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