Influences of Modified Borage Oil Rich in γ-Linolenic Acid and Linseed Oil Rich in α-Linolenic Acid on MRL/lpr Mice
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- Mei Lin
- Faculty of Agriculture, Meijo University
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- Ohara Akihiro
- Faculty of Agriculture, Meijo University
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- Nagao Toshihiro
- Osaka Municipal Technical Research Institute
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- Kawashima Akiko
- Sonoda Women's University
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- Shimada Yuji
- Osaka Municipal Technical Research Institute
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- Matsuhisa Tsugio
- Faculty of Agriculture, Meijo University
Bibliographic Information
- Other Title
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- 改質したγ-リノレン酸高含有ボラージ油とα-リノレン酸高含有亜麻仁油が自己免疫疾患易発症マウスMRL/lprに及ぼす影響
- カイシツ シタ ガンマ リノレンサン コウガンユウ ボラージユ ト アルファ リノレンサン コウガンユウ アマニユ ガ ジコ メンエキ シッカンイハッショウ マウス MRL lpr ニ オヨボス エイキョウ
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Abstract
Effects of omega 3 and omega 6 unsaturated fatty acids on the autoimmune factors in MRL/lpr prone mice were investigated. Linseed oil was used as alpha-linolenic acid-rich oil (about 56%). Gamma-linolenic acid-rich oil containing the same amount as alpha-linolenic acid in linseed oil was prepared from borage oil. These oils and soybean oil were fed to the mice from 8 weeks old to 20 weeks old. Body weight of gamma-linolenic acid-rich oil group was significantly lower than that of alpha linolenic acid-rich oil group. Spleen swelling was suppressed by the administration of alpha and gamma-linolenic acids-rich oils, compared with soybean oil group. The suppression of the production of autoantibody and the decrease in urine albumin concentration were also observed. The administration of alpha-linolenic acid reduced the production of TNF-alpha, IL-1beta, and IL-6. Gamma-linolenic acid group gave the intermediate score. The production of IL-18 showed the highest value in soybean oil group.
Journal
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- Japanese Journal of Food Chemistry and Safety
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Japanese Journal of Food Chemistry and Safety 13 (3), 125-130, 2006
Japanese Society of Food Chemistry
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Details 詳細情報について
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- CRID
- 1390001205195232256
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- NII Article ID
- 110007367344
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- NII Book ID
- AA11666400
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- ISSN
- 21896445
- 13412094
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- NDL BIB ID
- 8666316
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed