Effects of Various Dietary Supplements on the Cardiovascular Functions of Rats

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  • Kubota Yoko
    School of Pharmaceutical Sciences, Mukogawa Women's University Institute for Biosciences, Mukogawa Women's University
  • Umegaki Keizo
    National Institute of Health & Nutrition
  • Tanaka Naoko
    School of Pharmaceutical Sciences, Mukogawa Women's University
  • Mizuno Hideya
    School of Pharmaceutical Sciences, Mukogawa Women's University
  • Nakamura Kazuki
    School of Pharmaceutical Sciences, Mukogawa Women's University
  • Kunitomo Masaru
    School of Pharmaceutical Sciences, Mukogawa Women's University Institute for Biosciences, Mukogawa Women's University
  • Shinozuka Kazumasa
    School of Pharmaceutical Sciences, Mukogawa Women's University Institute for Biosciences, Mukogawa Women's University

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  • ラット循環機能に対する各種健康食品の4週間反復投与の影響
  • ラット ジュンカン キノウ ニ タイスル カクシュ ケンコウ ショクヒン ノ 4シュウカン ハンプク トウヨ ノ エイキョウ

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Abstract

Catechins, isoflavones, octacosanol, sodium iron chlorophyllin and sodium copper chlorophyllin have been increasingly used as a dietary supplement in Japan. In the present study, the effects of these dietary supplements on the cardiovascular function of male Wistar rats were examined by fed these dietary supplements diet for 4 weeks. After 4 weeks, the liver, aorta and atria were isolated from rats. All dietary supplements diet did not change the heart rate and blood pressure. Isoproterenol-induced positive and acetylcholine-induced negative inotropic and chronotropic effects on the atria were not affected by all dietary supplements diet. Acetylcholine and sodium nitroprusside-induced relaxation of the aortic rings was not also affected by all dietary supplements diet. Although, the feeding of isoflavones diet significantly increased the ratio of liver weight per 100 g body weight, the others did not (Table). Blood transaminase activity was unaltered by the feeding of all dietary supplements diet. These results suggested that these dietary supplements did not change the cardiovascular functions, but also had no obvious toxicity. Table Body weight and liver weight [table]

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