The effect of leptin gene polymorphisms on fertility traits in Japanese Black cattle

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  • KAWAGUCHI Fuki
    Graduate School of Agricultural Science, Kobe University
  • FUKAZAWA Kenji
    Graduate School of Agricultural Science, Kobe University
  • KOHAMA Namiko
    Northern Center of Agricultural Technology, General Technological Center of Hyogo Prefecture for Agriculture, Forest and Fishery
  • AKIYAMA Takayuki
    Northern Center of Agricultural Technology, General Technological Center of Hyogo Prefecture for Agriculture, Forest and Fishery
  • FUKUSHIMA Moriyuki
    Northern Center of Agricultural Technology, General Technological Center of Hyogo Prefecture for Agriculture, Forest and Fishery
  • KOBAYASHI Eiji
    Animal Breeding and Reproduction Research Division, NARO Institute of Livestock and Grassland Science
  • OYAMA Kenji
    Food Resources Education & Research Center, Kobe University
  • MANNEN Hideyuki
    Graduate School of Agricultural Science, Kobe University
  • SASAZAKI Shinji
    Graduate School of Agricultural Science, Kobe University

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Other Title
  • 黒毛和種繁殖雌牛集団におけるレプチン遺伝子内多型と繁殖形質との関連
  • クロゲワシュ ハンショク メウシ シュウダン ニ オケル レプチン イデンシ ナイ タケイ ト ハンショク ケイシツ ト ノ カンレン

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Abstract

<p>In this study, we investigated the effect of leptin gene polymorphisms on fertility traits in Japanese Black cattle of Hyogo Prefecture (n＝409). Three amino acid substitutions (Y7F, R25C, and A80V) were identified by sequence comparison of full-length coding region among 16 animals. We genotyped these substitutions for 409 animals and then analyzed the effects on three fertility traits (calving interval, age at first calving, and the number of calves produced at 4 years of age). As the result, Y7F and R25C were associated with the calving interval (P<0.05). In addition, Y7F and R25C were in strong linkage disequilibrium (r2＝0.88). However, Y7F is not so important in mature leptin because this position is cleaved off before leptin is excreted from the adipose tissue. These results suggested that the effect of Y7F on the calving interval may be due to the linkage disequilibrium with R25C and R25C would be used as effective DNA marker for the improvement of calving interval.</p>

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