Effects of Cholecystokinin Administration into the Third Ventricle on Feed Intake in Goats

DOI Web Site 14 References

Bibliographic Information

Other Title
  • ヤギにおける採食量に及ぼす第三脳室内Cholecystokinin投与の影響
  • Effects of Cholecystokinin Administrati

Search this article

Abstract

To evaluate the anoretic effect of Cholecystokinin (CCK) in goats, CCK (sulfated CCK -8) was administered into the third ventricle of the brain either by a bolus injection or continuous infusion in five castrated male goats which were deprived feed for 22 hours. The injection doses of CCK were 400, 1, 600 and 3, 200pmol, and the infusion rates were 50, 200 and 400 pmol/h, respectively. The injections were given just before feeding, whereas the continuous infusions, which lasted for 1 hour, were started 30 minutes before feeding. The injection of CCK resulted in a temporal but drastic decrease in feed intake in the initial 15 min of feeding and led to a decrease in the cumulative feed intake over 2 hours, the extent depending upon the dose. When CCK was administered by continuous infusion, the anoretic effect was more pronounced. Feeding behavior was almost completely suppressed during the infusion period and the decrease in cumulative feed intake was not only dose dependent but also much larger than for a bolus injections. From these results it was concluded that CCK administration into the third ventricle exerts an anoretic effect in conscious goats, dose dependently with much lower doses for continuous infusion causing an effect compared with the bolus injection.

Journal

References(14)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top