Effect of Intravenous Injection of Short Chain Fatty Acids on Glucagon Secretion in Sheep

  • MINED Hitoshi
    Department of Veterinary Medicine, Rakuno Gakuen University
  • MURAO Ryota
    Department of Veterinary Medicine, Rakuno Gakuen University
  • KATO Seiyu
    Department of Veterinary Medicine, Rakuno Gakuen University
  • USHIJIMA Jun-ichi
    Department of Veterinary Medicine, Rakuno Gakuen University

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Other Title
  • ヒツジのグルカゴン分泌に及ぼす短鎖脂肪酸静脈内投与の影響
  • ヒツジ ノ グルカゴン ブンピ ニ オヨボス タン サ シボウサン ジョウミャ

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Abstract

The effect of intravenous injection of short chain fatty acids on glucagon secretion was examined in conscious sheep. Each acid was injected at a dose of 625 μmol/kg body weight. Plasma glucagon and glucose concentrations were determined after injection of each short chain fatty acid. All sodium salt solution of short chain fatty acids (propionate, n-butyrate, n-valerate and n-caproate), except for acetate, have stimulating activity on glucagon secretion in sheep in vivo. These results may indicate that the plasma glucagon levels are regulated by short chain fatty acids produced by rumen fermentation in ruminants.

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