A 26-week Repeated Dietary Dose Toxicity Study of Free-type or Ca-type Garcinia Extract in Rats

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  • Anno Takahiko
    Food Development Laboratories, Nippon-shinyaku Co. Ltd.
  • Oono Hiromi
    Food Development Laboratories, Nippon-shinyaku Co. Ltd.
  • Tomi Hironori
    Food Development Laboratories, Nippon-shinyaku Co. Ltd.
  • Kishida Koichi
    Toxicology Department, Developmental Research Laboratory, Nippon-shinyaku Co. Ltd.
  • Ishibashi Seitaro
    Toxicology Department, Developmental Research Laboratory, Nippon-shinyaku Co. Ltd.
  • Iwakura Keiko
    Toxicology Department, Developmental Research Laboratory, Nippon-shinyaku Co. Ltd.

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  • フリータイプ及びCaタイプのガルシニアエキスの雄ラットを用いた26週間反復混餌投与毒性試験
  • フリータイプ オヨビ Ca タイプ ノ ガルシニアエキス ノ オス ラット オ モチイタ 26シュウカン ハンプクコンジ トウヨ ドクセイ シケン

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Garcinia extract, which is extracted from the rind of the Indian fruit, Garcinia cambogia, is available as an herbal supplement and is used to reduce weight. In the present study, free-type or Ca-type Garcinia extract was fed to F344/DuCrj male rats at a dose of 0.2%, 1.0% or 5.0% as a dietary admixture for 13 or 26 weeks, in order to study their toxicity. 1. No mortality during the administration period was observed in all groups including control. Soft stool was sporadically observed in all groups. 2. Body weight gain was suppressed only in the 5.0% of Ca-type extract given group on 1-, 4- and 10-week, and lowered body weight was observed on 4-between 8-week and on 10-between 12-week. 3. There were no toxicological changes in food consumption, in intake of Garcinia extract, in hematology, in blood chemistry and in organ weights. 4. As a result of toxicokinetics, (-)-hydroxycitric acid concentrations in plasma were almost or less than detection (20μg/mL) limit in each group. 5. The pathological examination revealed no marked changes in the gross findings in free-type extract given group on 13- or on 26-week. In 5.0% of Ca-type given group on 26-week, there was one case showing small size of testes, seminal vesicle, prostate and soft testes. 6. As a result of the histological examination, there were no toxicological changes in free-type extract given group on 13- or 26-week. In 5.0% of Ca-type given group on 13-week, there were seven cases showing very slight or slight atrophy of seminiferous tubules, on 26-week, one case had interstitial edema in testes, decreased sperm counts in epididymides, atrophy of seminiferous tubules, seminal vesicle, prostate, 4 cases showed very slight or slight atrophy of seminiferous tubules. These results indicate that the no adverse effect level of free-type Garcinia extract was 5.0% and that of Ca-type Garcinia extract was 1.0%, under the conditions of this study.

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