Gender differences in left ventricular function including diastolic function in patients with normal left ventricular ejection fraction and normal echocardiographic findings

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  • 心エコー所見正常者の拡張能を含む心機能の男女差

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Several studies indicated that there were gender differences in left ventricular (LV) systolic function. Gender differences in left ventricular diastolic function were also reported. However, there has been no study about gender differences in left ventricular diastolic function in Japanese. The purpose of this study is to assess gender differences in left ventricular function including diastolic function in patients with normal left ventricular ejection fraction and normal echocardiographic findings. Subjects were 163 patients under 60 years of age, including 108 men and 55 women, with LV ejection fraction (EF) over 65%. LVEF, both mitral E and A wave velocities, mitral E/A ratio, deceleration time of E wave (DcT), Tei index, ejection time (ET), isovolumetric relaxation time (IRT), isovolumetric contraction time (ICT) and left ventricular mass index (LVMI) were measured using Doppler echocardiography. Patients with hypertension and diabetes mellitus were then excluded from the 163 patients, which left 134 patients including 85 men and 49 women to be analyzed. There was no difference in LVEF between genders. E wave velocity (79±19 vs 69±15 cm/s, p<0.005) was higher in women than in men, but A wave velocity, DcT and E/A ratio were not different between genders. ET (311±23 vs 292±31 ms, p<0.005) was longer in women than in men, but ICT and IRT were not different between genders. Tei index (0.38±0.11 vs 0.44±0.12, p<0.005) was smaller in women than in men, probably because of a gender difference in ET. LVMI (102±29 vs 119±25g/m2, p<0.005) was smaller in women than in men. We conclude that it is necessary to pay attention to these gender differences when evaluating left ventricular function.

Journal

  • Choonpa Igaku

    Choonpa Igaku 34 (3), 343-348, 2007

    The Japan Society of Ultrasonics in Medicine

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