Disseminated Discoid Lupus Erythematosus in a Dog

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  • 犬の播種状円板状エリテマトーデスの1例

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A 12-year-old male beagle dog presented with disseminated scaly alopecia, infiltrative erythema on the face and extremities, and mild lymphadenopathy. Histopathological findings showed hyperkeratosis with follicular plugging, hydropic degeneration of the basal cell layer, and inflammation of lymphocytes and plasma cells with mucinosis of the superficial dermis and perifollicular areas. Direct immunofluorescence study showed linear deposition of IgG at the dermal-epidermal junction. Complete blood counts revealed mild anemia and leukopenia, but antinuclear antibody was negative. The present case closely resembled those found in humans with disseminated discoid lupus erythematosus. The dog improved with avoidance of sunlight and systemic prednisolone therapy, but required continuous low-dose steroid administration.<br>

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