Fimbria-Fornix (FF) lesions in rats impair the use of spatial information in the water maze

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  • SAKAMOTO Toshiro
    Research fellow of the Japan Society for the Promotion of Science, Department of Psychology, Doshisha University
  • OKAICHI Hiroshige
    Department of Psychology, Doshisha University

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Other Title
  • 海馬采-脳弓損傷ラットが示す水迷路内の空間情報の利用障害
  • カイバサイーノウキュウ ソンショウ ラット ガ シメス ミズ メイロ ナイ ノ クウカン ジョウホウ ノ リヨウ ショウガイ

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In order to examine the role of the hippocampus in use of spatial information, fimbria-fornix lesioned (FF) rats and control rats were trained for the place learning tasks in a Morris water maze. In experiment 1, FF rats were impaired in the retention of the task in which extra-maze stimuli were available, but control rats were not. In experiment 2, the water maze was enclosed by curtains, and two objects of different appearance were hung on the water surface as intra-maze stimuli. The hidden platform was distant from the two objects, but the spatial relationship of the platform and two objects was kept constant in the pool throughout the training. The performance of the FF rats was inferior to that of control rats, although they could solve this task using only response strategy. Control rats could solve the task using both the spatial information in the maze (the place strategy) and the response strategy. These results indicated that the hippocampus plays an important role in using the spatial relationship among available stimuli, whether extra-maze (distal) stimuli or intra-maze (proximal) stimuli.

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