Expression Pattern of WWP1 in Muscular Dystrophic and Normal Chickens
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- Matsumoto Hirokazu
- Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
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- Maruse Hideaki
- Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
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- Sasazaki Shinji
- Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
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- Fujiwara Akira
- Laboratory Animal Research Station, Nippon Institute for Biological Science, Japan
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- Takeda Shin'ichi
- Department of Molecular Therapy Japan
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- Ichihara Nobutsune
- Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Japan Department of Anatomy I, School of veterinary medicine, Azabu University, Japan
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- Kikuchi Tateki
- Department of Molecular Therapy Japan
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- Mukai Fumio
- Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
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- Mannen Hideyuki
- Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Japan
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Abstract
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is classified into one of ubiquitin ligases which play an important role in ubiquitin-proteasome pathway. Previously, we identified the WWP1 gene as a candidate gene of chicken muscular dystrophy by linkage analysis and sequence comparison. However, the mechanism causing pathological changes and underlaying gene function remains elucidated. In the present study, we analyzed the WWP1 gene expression in various muscles and tissues of normal chickens, and compared with those from muscular dystrophic chickens. Two mRNA isoforms were detected in all tissues examined and revealed almost equal expression level. The WWP1 expression of dystrophic chickens was decreased in almost all skeletal muscles including unaffected muscles. These data indicate that there might not be a causal relationship between the alteration of WWP1 expression level and the severity of muscular dystrophy.
Journal
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- The Journal of Poultry Science
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The Journal of Poultry Science 46 (2), 95-99, 2009
Japan Poultry Science Association
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Details 詳細情報について
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- CRID
- 1390001205208193408
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- NII Article ID
- 130004446291
- 10024799250
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- NII Book ID
- AA11564513
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- ISSN
- 13490486
- 13467395
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- NDL BIB ID
- 10209691
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed