Metabolism of Diethofencarb in Rats
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- SHIBA Kunio
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- KANEKO Hideo
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- KAKUTA Noriko
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- YOSHINO Hiromi
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- IBA Kazuhiko
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- NAKATSUKA Iwao
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- YOSHITAKE Akira
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
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- YAMADA Hirohiko
- Biochemistry & Toxicology Laboratory, Sumitomo Chemical Co., Ltd.
Bibliographic Information
- Other Title
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- Diethofencarb のラットにおける代謝
- Diethofencarbのラットにおける代謝〔英文〕
- Diethofencarb ノ ラット ニ オケル タイシャ エイブン
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Abstract
Metabolic fates of diethofencarb (isopropyl 3, 4-diethoxycarbanilate) were examined in male and female rats. After single oral doses of [phenyl-14C]diethofencarb at 10mg/kg or 300mg/kg, most of the dosed 14C was recovered in the urine and feces within 48hr after dosing. The total 14C-recovery ranged from 99 to 100% of the dose during 7 days after administration with the 14C urinary excretion being 80 to 88% of the dose. 14C-Levels in the blood and various tissues reached maxima within 0.5hr after administration and decreased rapidly thereafter with biological half-lives of 12 to 35hr. 14C-Tissue residues were substantially low. The residue levels were the highest in the liver (0.05-0.07 and 1.70-2.22ppm for the low and high doses, respectively). Total tissue residues of 14C on the 7th day after dosing were less than 0.2% of the dose. Major metabolic reactions of diethofencarb were (1) de-ethylation of the 4-ethoxy group, (2) cleavage of the carbamate linkage, (3) acetylation of the amino group and (4) conjugation of the resultant phenols with sulfuric acid or glucuronic acid. A major metabolite in the urine was the sulfate of isopropyl 3-ethoxy-4-hydroxycarbanilate (30.0-48.7% of the dose). No marked sex-related difference was observed in the metabolism of diethofencarb.
Journal
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- Journal of Pesticide Science
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Journal of Pesticide Science 15 (3), 395-403, 1990
Pesticide Science Society of Japan
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Details 詳細情報について
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- CRID
- 1390001205209140608
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- NII Article ID
- 110001712370
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- NII Book ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
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- NDL BIB ID
- 3682597
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- Web Site
- https://agriknowledge.affrc.go.jp/RN/2010470705
- http://id.ndl.go.jp/bib/3682597
- https://ndlsearch.ndl.go.jp/books/R000000004-I3682597
- http://www.jstage.jst.go.jp/article/jpestics1975/15/3/15_3_395/_pdf
- http://dl.ndl.go.jp/info:ndljp/pid/10875296
- https://search.jamas.or.jp/link/ui/1993138733
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed