Tissue Distribution and Excretion of 4, 5-<sup>14</sup><i>C</i>-ethylenethiourea in Male Japanese Quail

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  • SAKAMOTO Tuyoshi
    Agricultural Chemicals Inspection Station, Ministry of Agriculture, Forestry and Fisheries

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  • 雄ウズラに経口投与した4,5-<sup>14</sup><i>C</i>-エチレンチオウレアの体内での分布と排泄
  • 雄ウズラに経口投与した4,5-14C-エチレンチオウレアの体内での分布と排出〔英文〕
  • ユウ ウズラ ニ ケイコウ トウヨシタ 4 5 14C エチレンチオウレア ノ

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Abstract

Male Japanese quail (Coturnix coturnix japonica) were orally administered 4, 5-14C-ETU by a stomach tube in order to investigate tissue distribution and excretion. The radioactivity derived from 14C-ETU was distributed throughout the body at almost similar levels 1hr after administration, and eliminated rapidly from the tissues except thyroid, eyeball and immature calamus, reaching levels of less than 1/10 of maximum within 24hr after administration. The levels of radioactivity in thyroid and eyeball were 500 and 43 times that of in liver at 96hr after administration, respectively. The results indicated that ETU and/or its metabolites have specifically accumulated in eyeball (retina or uveal tract), immature calamus as well as thyroid, where a similar phenomenon has been reported with rats and guinea pigs. The elimination half-lives of the radioactivity in thyroid and eyeball were 84 and 126hr, respectively. The radioactivity excreted in excreta (urine and feces) amounted to 77.3% of the administered radioactivity 48hr after administration, but the subsequent excretion was negligible.

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