Ferric methanearsonate (MAF) のラット体内における動態

DOI NDLデジタルコレクション 日本農学文献記事索引 Web Site

書誌事項

タイトル別名
  • Metabolic Fate of Ferric Methanearsonate (MAF) in Rat

この論文をさがす

抄録

When rats were given a single oral dose of ferric methanearsonate [(CH3AsO3)3Fe2; MAF] at 100mg/kg (As= 37.56mg/kg), about 52 and 12% of dose were excreted in the feces and urine, respectively, in a day after the administration, and thereafter the remaining arsenic was excreted much slowly. More than 90% of the arsenic in whole body was retained in the blood for a long term. The biological half life for arsenic in the blood was 114 days. Most of the arsenic was moved with the blood and deposited in the organs and tissues. A part of the arsenic was translocated to the hair. Higher arsenic levels were noted in the spleen throughout the experiment and in the kidney for the early stage after the dose. Lower accumulation of arsenic was observed in other organs.<br>In order to estimate blood contents in organs, hemoglobin (Hb) contents were spectrophotometrically determined to the cyanmethemoglobin method. Arsenic contents in the organs were closely related to the Hb contents in the corresponding organs except kidney.<br>Thin layer chromatographic analysis of the samples of urine, feces, blood and kidney indicated the presence of three major arsenic components. These components were identified as dimethylarsinate [cacodylate; salt of dimethylarsinic acid ((CH3)2AsO2H; DMAA)], methanearsonate [salt of methanearsonic acid (CH3AsO3H2; MAA)] and arsenate (As+5) by spectrophotometry with silver diethyldithiocarbamate (AgDDC) and gas chromatography-mass spectrometric (GC-MS) analyses. The presence of dimethylarsinate as the predominant component in the blood indicated the methylation of arsenic occurred in the rat body.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ