Metabolism of <i>N</i>-(1-Methyl-1-phenylethyl)-2-bromo-3, 3-dimethylbutanamide (Bromobutide) in Rats
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- ISOSE Naohiko
- Research Laboratory, Pesticides Division, Sumitomo Chemical Co., Ltd.
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- MATSUO Masatoshi
- Research Laboratory, Pesticides Division, Sumitomo Chemical Co., Ltd.
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- MIYAMOTO Junshi
- Research Laboratory, Pesticides Division, Sumitomo Chemical Co., Ltd.
Bibliographic Information
- Other Title
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- <i>N</i>-(1-Methyl-1-phenylethyl)-2-bromo-3,3-dimethylbutanamide (bromobutide) のラットにおける代謝
- N-(1-Methyl-1-phenylethyl)-2-bromo-3,3-dimethyl-butanamide(bromobutide)のラットにおける代謝〔英文〕
- N 1 Methyl 1 phenylethyl 2 bromo 3 3 di
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Description
With single oral administration of 14C-carbonyl- or 14C-phenyl-labeled bromobutide, N-(1-methyl-1-phenylethyl)-2-bromo-3, 3-dimethylbutanamide to male and female rats at the rate of 5mg/kg b. w., the radiocarbon was excreted rapidly and completely into the feces and urine. Residue levels of 14C in tissues and organs were less than 0.11μg bromobutide eq/g tissue in male and 0.07μg bromobutide eq/g tissue in female on the 7th day after administration. The bromobutide dosed was mainly metabolized by phenyl- and t-butyloxidation, debromination, and glucuronidation. In particular, the metabolites which had received the oxidation reactions accounted for 32-40% and 58-63% of the bromobutide dosed, respectively and the debrominated products including debromo-bromobutide amounted to more than 50% forming the major metabolic pathways. In contrast, the hydroxylated products of the methyl group in amine moiety were found only in small quantity and little amide hydrolysates, sulfate- and amino acid-conjugates were detected in feces and urine. When male rats were treated with higher dose (125mg/kg b. w.) of 14C-carbonyl-bromobutide, the less oxidized metabolites were excreted to higher extents, but little changes were observed in the members of metabolites.
Journal
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- Journal of Pesticide Science
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Journal of Pesticide Science 8 (4), 451-465, 1983
Pesticide Science Society of Japan
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Details 詳細情報について
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- CRID
- 1390001205210134528
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- NII Article ID
- 110001711803
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- NII Book ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
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- NDL BIB ID
- 2611923
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed