ALS阻害型除草剤KIH-2023のラットにおける代謝

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タイトル別名
  • Metabolism of ALS Inhibitory Herbicide Bispyribac-sodium [KIH-2023] in Rats
  • ALS阻害型除草剤KIH-2023のラットにおける代謝〔英文〕
  • ALS ソガイガタ ジョソウザイ KIH-2023 ノ ラット ニ オケル タ

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Absorption, distribution and metabolism of Bispyribac-sodium [sodium 2, 6-bis (4, 6-dimethoxypyrimidin-2-yloxy) benzoate] or [KIH-2023] in rats orally dosed with 14C-KIH-2023 were investigated. More than 90% of the dosed radioactivity was detected in the excreta within 96hr after dosing. Level of the radioactivity in the blood of male and female rats reached maxima at 2 and 1hr after dosing, respectively, and then decreased rapidly to about a half level of maxima (C1/2). The radioactivity of tissues was lower at 96hr after dosing than that at C1/2-time. Most of the radioactivity in the urine, feces, liver and plasma was detected as unchanged KIH-2023. The major radioactive compounds excreted into the bile were KIH-2023 and its glucuronide. Repeated oral administration of KIH-2023 for 15 days gave similar results from the single oral one in the excretion, tissue distribution and metabolism of 14C-KIH-2023.

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