1, 3, 5-トリアジン系硝酸化成抑制剤の作用部位

村上 学, 高木 聡子, 高橋 巌, 徳山 龍明, 佐藤 幸治, VONK Johannes Willem, 若林 攻

doi:10.1584/jpestics.20.471

Trichloromethyl-1, 3, 5-triazines were synthesized and their nitrification inhibitory activity in upland soil was evaluated by measuring pI₅₀ (soil) values, the negative logarithm of molar I₅₀ (soil). Furthermore, pI₅₀ (soil-water) values were calculated using the soil adsorption coefficient. Measurement of accumulated nitrification intermediates, NH₂OH and NO₂^--N, revealed a possibility that the nitrite formation step was blocked by the triazine inhibitors. The active triazines inhibited ammonia-oxidation step, but did not inhibit hydroxylamineoxidation step in Nitrosomonas europaea ATCC 25978. The formers inhibitory indices were expressed as pI₅₀ (cell suspension) values. These results suggest that the target enzyme of 1, 3, 5-triazine nitrification inhibitors may be the ammonia monooxygenase in N. europaea ATCC 25978. In addition, a good correlation was found between the three types of pI₅₀-values and hydrophobic parameter, logP, by quantitative structure activity relationship. The optimum logP values in the three equations obtained using pI₅₀ (soil), pI₅₀ (soil-water) and pI₅₀ (cell suspension) values, were calculated as 2.65, 5.03 and 5.04, respectively.

1, 3, 5-トリアジン系硝酸化成抑制剤の作用部位

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1, 3, 5-トリアジン系硝酸化成抑制剤の作用部位

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