ラットにおける急性ピレスロイド中毒のメトカルバモールによる治療効果

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  • 廣森 壽彦
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • 中西 とし子
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • 川口 幸子
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • 佐古 博
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • 鈴木 隆
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.
  • 宮本 純之
    Laboratory of Biochemistry and Toxicology, Takarazuka Research Center, Sumitomo Chemical Co., Ltd.

書誌事項

タイトル別名
  • Therapeutic Effects of Methocarbamol on Acute Intoxication by Pyrethroids in Rats
  • ラットにおける急性ピレスロイド中毒のメトカルバモールによる治療効果〔英文〕
  • ラット ニ オケル キュウセイ ピレスロイド チュウドク ノ メトカルバモー

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抄録

The therapeutic potency of intraperitoneally administered methocarbamol was examined against acute oral intoxication of rats caused by lethal doses of pyrethroids (fenvalerate, cypermethrin, fenpropathrin and permethrin). Methocarbamol was initially administered a dose of 400mg/kg (body weight), followed by repeated doses of 200mg/kg, when tremors or hyperexcitability to sound was observed. Methocarbamol markedly decreased the mortality; 80% mortality caused by an administration of 850mg/kg (body weight) fenvalerate to 0%, 80% mortality by 850mg/kg cypermethrin to 0%, 60% mortality by 100mg/kg fenpropathrin to 0% and 70% mortality by 850mg/kg permethrin to 10%, and it was effective in alleviating motor symptoms such as fibrillation, tremors, hyperexcitability, clonic seizures and/or choreoathetotic movements. A subcutaneous administration of 25mg/kg (body weight) atropine sulfate was also effective in mitigating salivation produced by fenvalerate and cypermethrin.

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