Synthesis and antifungal activity of novel 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety

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  • Zhang Zeyuan
    College of Chemistry and Material Science, Shandong Agricultural University College of Chemistry and Material Science, Shandong Agricultural University
  • Mu Wei
    College of Plant Protection, Shandong Agricultural University College of Plant Protection, Shandong Agricultural University
  • Ji Zengchen
    College of Plant Protection, Shandong Agricultural University College of Plant Protection, Shandong Agricultural University
  • Jiang Lin
    College of Chemistry and Material Science, Shandong Agricultural University College of Chemistry and Material Science, Shandong Agricultural University

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Eighteen novel compounds of 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety were synthesized from 1H-benzimidazole-2-carbohydrazide, carbon disulfide and alkyl halide or benzyl halide by multi-step reactions. The structures of the target compounds were confirmed by IR, 1H-NMR spectra and elemental analyses. Preliminary antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were also evaluated by the mycelium growth rate method, and the results indicated that many target compounds possess excellent antifungal activity, even higher than the control fungicide (carbendazim).

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