Long-term Sequential Changes of Radiation Proctitis and Angiopathy in Rats
-
- DOI Hiroshi
- Department of Radiology, Hyogo College of Medicine
-
- KAMIKONYA Norihiko
- Department of Radiology, Hyogo College of Medicine
-
- TAKADA Yasuhiro
- Department of Radiology, Hyogo College of Medicine
-
- FUJIWARA Masayuki
- Department of Radiology, Hyogo College of Medicine
-
- TSUBOI Keita
- Department of Radiology, Hyogo College of Medicine
-
- MIURA Hideharu
- Department of Radiology, Hyogo College of Medicine
-
- INOUE Hiroyuki
- Department of Radiology, Hyogo College of Medicine
-
- TANOOKA Masao
- Department of Radiology, Hyogo College of Medicine
-
- NAKAMURA Takeshi
- Department of Pharmacy, The Hospital of Hyogo College of Medicine
-
- SHIKATA Toshiyuki
- Department of Pharmacy, The Hospital of Hyogo College of Medicine
-
- KIMURA Takeshi
- Department of Pharmacy, The Hospital of Hyogo College of Medicine
-
- TSUJIMURA Tohru
- Department of Pathology, Hyogo College of Medicine
-
- HIROTA Shozo
- Department of Radiology, Hyogo College of Medicine
この論文をさがす
抄録
The purpose of the present study was to establish an experimental rat model for late radiation proctitis, and to examine the assessment strategy for late radiation proctitis. A total of 57 Wistar rats were used. Fourty-five of the rats were exposed to selective rectal irradiation with a single fraction of 25 Gy. These rats were sacrificed at the 4th, 12th, 24th, and 37th week following irradiation. The remaining 12 rats comprised the control group without irradiation. The rectal mucosa of each rat was evaluated macroscopically and pathologically. The number of vessels in the rectal mucosa was counted microscopically. In addition, the vascular stenosis was evaluated. In the results, the degree of clinical and macroscopic findings decreased following acute proctitis and developed later. In the pathological examination, mucosal changes and microangiopathy were followed up, as well. The absolute number of vessels in the rectum was the greatest at the 12th week following irradiation and was the lowest in the control group. The severity of the microangiopathy was also well evaluated. To conclude, we established an animal experimental model of late radiation proctitis, and also established an assessment strategy to evaluate objectively the severity of late radiation proctitis with focusing on microangiopathy using an animal experimental model. This model can be used as an animal experimental model of radiation-induced microangiopathy.
収録刊行物
-
- Journal of Radiation Research
-
Journal of Radiation Research 53 (2), 217-224, 2012
Journal of Radiation Research 編集委員会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205215066368
-
- NII論文ID
- 130001876825
-
- NII書誌ID
- AA00705792
-
- COI
- 1:STN:280:DC%2BC38rlsl2htw%3D%3D
-
- ISSN
- 13499157
- 04493060
-
- NDL書誌ID
- 023572135
-
- PubMed
- 22510594
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可