Ascorbic Acid Monoglucoside as Antioxidant and Radioprotector
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- MATHEW Dani
- Amala Cancer Research Centre, Amala Nagar
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- NAIR Cherupally Krishnan K.
- Amala Cancer Research Centre, Amala Nagar
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- JACOB Jasmin A.
- Chemistry Group, Bhabha Atomic Research Centre
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- BISWAS Nandita
- Chemistry Group, Bhabha Atomic Research Centre
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- MUKHERJEE Tulsi
- Chemistry Group, Bhabha Atomic Research Centre
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- KAPOOR Sudhir
- Chemistry Group, Bhabha Atomic Research Centre
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- KAGIYA Tsutomu V.
- Health Research Foundation
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Abstract
Ascorbic acid monoglucoside (AsAG), a glucoside derivative of ascorbic acid, has been examined for its antioxidant and radioprotective abilities. AsAG neutralized 1, 1 diphenyl -2-picryl-hydrazyl (DPPH), a stable free radical in a concentration dependent manner thus indicating its antioxidant ability. AsAG protected mice liver tissues in vitro from peroxidative damage in lipids (measured as TBARS) resulting from 25Gy γ irradiation. It also protected plasmid pBR322 DNA from gamma-radiation induced strand breaks as evidenced from studies on agarose gel electrophoresis of the plasmid DNA after radiation exposure. Oral administration of AsAG to mice prior to whole body gamma radiation exposure (4Gy) resulted in a reduction of radiation induced lipid peroxides in the liver tissue indicating in vivo radiation protection of membranes. Pulse radiolysis studies indicated that AsAG offered radioprotection by scavenging free radicals. The rate constants for the reactions OH and N3 radicals with AsAG were determined to be 6.4 × 109 dm 3 mol-1 s-1 and 2.3 × 109 dm3 mol-1 s -1, respectively at pH 7. It was observed that AsAG radicals undergo conjugation as the pH of the solution is raised to 11 in the case of a one-electron oxidation reaction. As the OH· radical adds to the ring, the conjugation effect starts appearing at pH 10.<br>
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 48 (5), 369-376, 2007
Journal of Radiation Research Editorial Committee
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Keywords
Details 詳細情報について
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- CRID
- 1390001205215202432
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- NII Article ID
- 110006388619
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- NII Book ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL BIB ID
- 8911763
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed