Concurrent Chemoradiotherapy with S-1 for T2N0 Glottic Squamous Cell Carcinoma
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- NONOSHITA Takeshi
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- SHIOYAMA Yoshiyuki
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- NAKAMURA Katsumasa
- Department of Radiology, Kyushu University Hospital at Beppu
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- NAKASHIMA Torahiko
- Department of Otorhinology, Graduate School of Medical Sciences, Kyushu University
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- OHGA Saiji
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- YOSHITAKE Tadamasa
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- OHNISHI Kayoko
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- TERASHIMA Kotaro
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- ASAI Kaori
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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- HONDA Hiroshi
- Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
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In this study, we evaluated the feasibility, efficacy and toxicity of concurrent chemoradiotherapy with S-1 (tegafur-gimeracil-oteracil potassium) for T2N0 glottic carcinoma. A total of 23 patients with T2N0 glottic carcinoma received chemoradiotherapy with S-1. Radiotherapy consisted of five daily fractions of 2 Gy per week, to a total median dose of 70 Gy. S-1 was administered 65 mg/m2 per day for 4 weeks, beginning on the day therapy was started, followed by 2 weeks off the drug and twice a day until the end of radiotherapy. Initial local control rate of the primary tumor was achieved in all patients. The median follow-up period for all patients was 38 months. The 3-year local control rate was 95.4%. Regarding adverse reactions, grade 3 mucositis upon clinical examination, mucositis upon functional/symptomatic examination, dysphagia, hepatic toxicity and anemia were observed in 13, 2, 2, 1 and 1 patients, respectively. This chemoradiotherapy did not result in grade 4 acute toxicity or severe late toxicity. Chemoradiotherapy with S-1 was feasible, well tolerated and effective. This therapy is suggested as a possible regimen for improving local control of T2N0 glottic carcinoma.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 51 (4), 481-484, 2010
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205215858304
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- NII論文ID
- 10026564129
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 10766194
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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