Effects of Carrier on the Retention, Excretion and Distribution of <SUP>144</SUP>Ce in the Rat

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  • TAKADA Kazuo
    Division of Health Physics and Safety, Japan Atomic Energy Research Institute
  • FUJITA Minoru
    Division of Health Physics and Safety, Japan Atomic Energy Research Institute
  • SUZUKI Masashi
    Division of Environmental Health, National Institute of Radiological Sciences

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  • Effects of Carrier on the Retention, Excretion and Distribution of 144Ce in the Rat

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Cerium-144 was injected intravenously into rats as the chloride with different amounts of carrier. After a single injection the whole body retention, daily fecal and urinary excretion, and tissue distribution were studied during about a month. The following results were obtained. Addition of carrier suppressed the early urinary excretion which was observed with carrier free Ce-144. A large amount of carrier markedly suppressed the fecal excretion which was the main excretory route of cerium. In general, the maximum value of fecal excretion was observed about a few days after injection, although it depended on the carrier level, and the whole body retention curves showed sigmoidal patterns. As the amounts of carrier increased, Ce-144 decreased in the bone and kidney, and increased in the liver and spleen. It seemed that, when the carrier level was low, intravenously injected Ce-144 showed relatively ionic nature but as the carrier increased it showed more colloidal nature.

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